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Our Botanicals

Kamedis skin relief products are made using the highest quality botanical extract combinations.
See below for more information on specific botanical herbs.

Rheum Palmatum (Rhubarb)
rhubarb botanical Main ingredients:
Anthraquinones (aloe-emodin, rhein, emodin) Actions based on scientific research: Anti-Inflammatory[1-4]



Reduces sebum secretion[10]

1. Cai, J. et al., Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer. Zhong Xi Yi Jie He Xue Bao. 2005. 3(3):195-8.

2. Zhao, YQ. et al., Protective effects of rhubarb on experimental severe acute pancreatitis. World J Gastroenterol. 2004. 1;10(7):1005-9.

3. Li, HL. et al., Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int J Mol Med. 2005. 16(1):41-7.
4. Dong, CM. et al., Prospective study of systemic inflammatory response syndrome of patients with nosocomial G- bacteria infection. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003, 15(11):666-8.
5. Yang, ZC. et al., The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005. 41(2-3):79-81.

6. Cyong J, et al., Anti-Bacteroides fragilis substance from Rhubarb. J Ethnopharmacol. 1987, 19(3):279-83.

7. Hatano, T. et al., Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Phytochemistry. 2005, 66(17):2047-55.

8. Masuda, H. et al., Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 2004. 12(18):4871-6.

9. Park, EK. et al., Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria. Arch Pharm Res. 2002. 25(4):528-33

10. Cha TL. et al., Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005, 15;65(6):2287-95.
Scutellaria Baicalensis (Skullcap)
skullcap botanical Main ingredients:
Actions based on scientific research: Anti-Inflammatory[1,2]


Regulates sebum[5]

1. Li, BQ. et al., The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology. 2000. 49(3):295-306.

2. Cuellar, MJ. et al., Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 2001,72(3):221-9.

3. Yang ZC. et al., The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005, 25;41(2-3):79-81.

4.Li BQ. et al., Inhibition of HIV infection by baicalin-a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res. 1993;39(2):119-24.

5. Ju Q, et al., Effects of baicalin and other Chinese herbal monomer on androgen receptor mRNA expression in SZ95 sebocytes. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007. 29(2):167-70.
Portulaca Oleracea (Purslane)
Purslane botanicalMain ingredients:
Flavonoids (kampferol, apigenin, quercetin)
Actions based on scientific research: Anti-inflammatory and analgesic for external use[1]

Supports healing of wounds[2]



1. Chan K. et al., The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa (Haw.) Celak. J Ethnopharmacol. 2000. 73:445-51

2. Rashed AN, et al., Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. J Ethnopharmacol. 2003. 88(2-3):131-6

3. Lim YH. et al., In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J Microbiol. 2007;45(5):473-7.

4. Huang Z, et al., Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for Cardiovascular Equality Project. Int J Food Sci Nutr. 2007, 18;1-9.
Cnidium Monnieri
Cnidium botanical Main ingredients:
Actions based on scientific research: Anti-Inflammatory[1-4]

Relieves itching[5]



1. Masuda, H. et al., Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull. 2002, 25(6):809-12.

2. Liu, SX and Chiou GC. Effects of Chinese herbal products on mammalian retinal functions. J Ocul Pharmacol Ther. 1996, 12(3):377-86.

3. Figueroa, M. et al., Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. J Ethnopharmacol. 2007, 113(1):125-31.

4. Cai, J. et al., Studies on the quality of fructus Cnidii--comparison of antibacterial action. Zhongguo Zhong Yao Za Zhi. 1991, 16(8):451-3, 510. 5. Masuda, H. et al., Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). Biol Pharm Bull. 2001, 24(9):1012-5.
Sapindus Mukorossi (Soapberry)
Soapberry botanicalMain ingredients:
Saponins (Hederagenin)
Actions based on scientific research: Anti-Inflammatory[1-4]



1. Ibrahim M, et al., Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies. World J Gastroenterol. 2006 , 28;12(44):7136-42.

2. Anisimov MM, et al., Chemical structure and antifungal activity of a number of triterpenoids. Biol Bull Acad Sci USSR. 1979, 6(4):464-8.

3. Choi J, et al., Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata. J Med Food. 2005, 8(1):78-85.
Glycyrrhiza glabra, Dipotassium glycyrrhizate (Licorice)
Licorice botanicalMain ingredients:
Dipotassium glycyrrhizate
Actions based on scientific research: Anti-Inflammatory[1-4]

Anti-microbial [3,4]


1. Schrofelbauer, B. et al., Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signaling. Biochem J. 2009. 421(3):473-82.

2.Azimov, MM. et al., Pharmacological study of the anti-inflammatory agent glyderinine. Farmakol Toksikol. 1988. 51(4):90-3.

3.Krausser, R. et al., In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites. J Antimicrob Chemother. 2004, 54(1):243-6.

4. Li, J. et al., Comparative analysis of the effect of glycyrrhizin diammonium and lithium chloride on infectious bronchitis virus infection in vitro. Avian Pathol. 2009, 38(3):215-21.

5. Zhang, L. et al., Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. J Pharm Pharmacol. 2006, 58(9):1257-64.
Indigofera tinctoria (Indigo)
Indigo botanicalMain ingredients:
Indigo and indirubin
Actions based on scientific research: Anti-inflammatory: inhibits pro-inflammatory cytokines (IFN-γ, IL-6)[1]

Modulates proliferation and differentiation[2] of keratinocytes

Inhibits T lymphocytes infiltration[2]


1. Kunikata T, et al., Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur J Pharmacol. 2000;20;410(1):93-100.

2. Lin YK. et al., The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis. Dermatology. 2007;214(2):155-61.

3. Sreepriya M. et al., Effect of Indigofera tinctoria Linn on liver antioxidant defense system during D-galactosamine/endotoxin-induced acute hepatitis in rodents. Indian J Exp Biol. 2001;39(2):181
Phellodendron Amurense (Amur Cork Tree )

Phellodendron botanicalMain ingredients:
Actions based on scientific research: Anti-Inflammatory[1-4]


Reduces sebum production[3]

1. Cuéllar MJ, et al., Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 2001 Mar ;72(3):221-9.

2. Yu HH, et al., Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005;8(4):454-61.

3. Seki T, Morohashi M. Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands. Skin Pharmacol. 1993;6(1):56-60.
Angelica Polymorpha Sinensis (Dong Quai)
angelica botanicalMain ingredients:
Ferulic acid
Actions based on scientific research: Anti-Inflammatory[1]

Heals wounds[2]

1. Chao WW et al. Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol. 2010 May 27;129(2):244-9. Epub 2010 Apr 3.

2.Zhao H et al., SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin/severe-combined immunodeficiency mouse chimera. Wound Repair Regen. 2006 Sep-Oct;14(5):593-601.
Taraktogenos Kurzii
Taraktogenos Kurzii botanicalMain ingredients:
Actions based on scientific research: Anti-Inflammatory[1]


1.Lima JA, Oliveira AS, de Miranda AL, Rezende CM, Pinto AC. Anti-inflammatory and antinociceptive activities of an acid fraction of the seeds of Carpotroche brasiliensis (Raddi) (Flacourtiaceae). Braz J Med Biol Res. 2005 Jul;38(7):1095-103. Epub 2005 Jul 4.

2.Levy L. The activity of chaulmoogra acids against Mycobacterium leprae. Am Rev Respir Dis. 1975 May;111(5):703-5.
Sanguisorba Officinalis (Great Burnet)
Great burnet botanicalMain ingredients:
Gallic acid, tannic Acid
Actions based on scientific research: Anti-allergic - inhibits histamine release[1]




1. Shin TY. et al., Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions. Immunopharmacol Immunotoxicol. 2002. 24(3):455-68.

2. Ravipati AS. et al., Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complement Altern Med. 2012. 6;12(1):173.

3. Kokoska L. et al., Screening of some Siberian medicinal plants for antimicrobial activity. J Ethnopharmacol. 2002. 82(1):51-3.

4. Masaki H. et al., Active-oxygen scavenging activity of plant extracts. Biol Pharm Bull. 1995.18(1):162-6

5. Plant extracts for the treatment and prevention of infection [App. No. PCT/IL2011/050081; Pub. No. WO 2012/090205 * International phase
Chrysanthemum Indicum
chrysanthemum botanicalMain ingredients:
Ailanthone, toosedanin
Actions based on scientific research: Anti-allergic (inhibits histamine release)[1,2]

Potent anti-inflammatory properties down-regulating TH2 cytokines such as IL-4 and IL-13[3,4]

1. Kumar D. et al., Antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb. Pharmacognosy Res. 2011. 3(3):220-4.

2. Kang TH. et al., Ailanthus altissima swingle has anti-anaphylactic effect and inhibits inflammatory cytokine expression via suppression of nuclear factor-kappaB activation. In Vitro Cell Dev Biol Anim. 2010. 46(1):72-81.

3. Jin M. et al., Antiasthmatic activity of luteolin-7-O-glucoside from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model. Biol Pharm Bull. 2009. 32(9):1500-3.

4. Jin MH. et al., Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. Biol Pharm Bull. 2006. 29(5):884-8.

5. PCT/IL2011/050081; Pub. No. WO 2012/090205 * International phase
Ailanthus Altissima (Tree of Heaven)
tree of heaven botanicalMain ingredients:

Actions based on scientific research: Anti-Inflammatory[1]


1. Han S. et al., The effect of linarin on LPS-induced cytokine production and nitric oxide inhibition in murine macrophages cell line RAW264.7. Arch Pharm Res. 2002. 25(2):170-7.

2. Huang C. et al., Study on spectral properties of Chinese herbal medicines additives in cosmetic. Guang Pu Xue Yu Guang Pu Fen Xi. 2004, 24(12):1649-51.