Our Botanicals

Kamedis skin relief products are made using the highest quality botanical extract combinations.
See below for more information on specific botanical herbs.

▼Rheum Palmatum (Rhubarb)

Main ingredients:
Anthraquinones (aloe-emodin, rhein, emodin) Actions based on scientific research: Anti-Inflammatory[1-4]

Anti-bacterial[5-7]

Anti-allergic[8,9]

Reduces sebum secretion[10]

References:
1. Cai, J. et al., Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer. Zhong Xi Yi Jie He Xue Bao. 2005. 3(3):195-8.

2. Zhao, YQ. et al., Protective effects of rhubarb on experimental severe acute pancreatitis. World J Gastroenterol. 2004. 1;10(7):1005-9.

3. Li, HL. et al., Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int J Mol Med. 2005. 16(1):41-7.
4. Dong, CM. et al., Prospective study of systemic inflammatory response syndrome of patients with nosocomial G- bacteria infection. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003, 15(11):666-8.
5. Yang, ZC. et al., The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005. 41(2-3):79-81.

6. Cyong J, et al., Anti-Bacteroides fragilis substance from Rhubarb. J Ethnopharmacol. 1987, 19(3):279-83.

7. Hatano, T. et al., Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus. Phytochemistry. 2005, 66(17):2047-55.

8. Masuda, H. et al., Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 2004. 12(18):4871-6.

9. Park, EK. et al., Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria. Arch Pharm Res. 2002. 25(4):528-33

10. Cha TL. et al., Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005, 15;65(6):2287-95.

▼Scutellaria Baicalensis (Skullcap)

Main ingredients:
Baicalin
Actions based on scientific research: Anti-Inflammatory[1,2]

Anti-microbial[3,4]

Regulates sebum[5]

References:
1. Li, BQ. et al., The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology. 2000. 49(3):295-306.

2. Cuellar, MJ. et al., Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 2001,72(3):221-9.

3. Yang ZC. et al., The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf B Biointerfaces. 2005, 25;41(2-3):79-81.

4.Li BQ. et al., Inhibition of HIV infection by baicalin-a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res. 1993;39(2):119-24.

5. Ju Q, et al., Effects of baicalin and other Chinese herbal monomer on androgen receptor mRNA expression in SZ95 sebocytes. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007. 29(2):167-70.

▼Portulaca Oleracea (Purslane)

Main ingredients:
Flavonoids (kampferol, apigenin, quercetin)
Actions based on scientific research: Anti-inflammatory and analgesic for external use[1]

Supports healing of wounds[2]

Anti-bacterial[3]

Anti-oxidant[4]

References:
1. Chan K. et al., The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa (Haw.) Celak. J Ethnopharmacol. 2000. 73:445-51

2. Rashed AN, et al., Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. J Ethnopharmacol. 2003. 88(2-3):131-6

3. Lim YH. et al., In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J Microbiol. 2007;45(5):473-7.

4. Huang Z, et al., Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for Cardiovascular Equality Project. Int J Food Sci Nutr. 2007, 18;1-9.

▼Cnidium Monnieri

Main ingredients:
Osthole
Actions based on scientific research: Anti-Inflammatory[1-4]

Relieves itching[5]

Anti-allergic[8,9]

Anti-microbial[3,4]

References:
1. Masuda, H. et al., Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull. 2002, 25(6):809-12.

2. Liu, SX and Chiou GC. Effects of Chinese herbal products on mammalian retinal functions. J Ocul Pharmacol Ther. 1996, 12(3):377-86.

3. Figueroa, M. et al., Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. J Ethnopharmacol. 2007, 113(1):125-31.

4. Cai, J. et al., Studies on the quality of fructus Cnidii--comparison of antibacterial action. Zhongguo Zhong Yao Za Zhi. 1991, 16(8):451-3, 510. 5. Masuda, H. et al., Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). Biol Pharm Bull. 2001, 24(9):1012-5.

▼Sapindus Mukorossi (Soapberry)

Main ingredients:
Saponins (Hederagenin)
Actions based on scientific research: Anti-Inflammatory[1-4]

Anti-bacterial[5-7]

Anti-fungal[2]

References:
1. Ibrahim M, et al., Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies. World J Gastroenterol. 2006 , 28;12(44):7136-42.

2. Anisimov MM, et al., Chemical structure and antifungal activity of a number of triterpenoids. Biol Bull Acad Sci USSR. 1979, 6(4):464-8.

3. Choi J, et al., Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata. J Med Food. 2005, 8(1):78-85.

▼Glycyrrhiza glabra, Dipotassium glycyrrhizate (Licorice)

Main ingredients:
Dipotassium glycyrrhizate
Actions based on scientific research: Anti-Inflammatory[1-4]

Anti-microbial [3,4]

Anti-allergic[8,9]

References:
1. Schrofelbauer, B. et al., Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signaling. Biochem J. 2009. 421(3):473-82.

2.Azimov, MM. et al., Pharmacological study of the anti-inflammatory agent glyderinine. Farmakol Toksikol. 1988. 51(4):90-3.

3.Krausser, R. et al., In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites. J Antimicrob Chemother. 2004, 54(1):243-6.

4. Li, J. et al., Comparative analysis of the effect of glycyrrhizin diammonium and lithium chloride on infectious bronchitis virus infection in vitro. Avian Pathol. 2009, 38(3):215-21.

5. Zhang, L. et al., Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. J Pharm Pharmacol. 2006, 58(9):1257-64.

▼Indigofera tinctoria (Indigo)

Main ingredients:
Indigo and indirubin
Actions based on scientific research: Anti-inflammatory: inhibits pro-inflammatory cytokines (IFN-γ, IL-6)[1]

Modulates proliferation and differentiation[2] of keratinocytes

Inhibits T lymphocytes infiltration[2]

Anti-oxidative[3]

References:
1. Kunikata T, et al., Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur J Pharmacol. 2000;20;410(1):93-100.

2. Lin YK. et al., The efficacy and safety of topically applied indigo naturalis ointment in patients with plaque-type psoriasis. Dermatology. 2007;214(2):155-61.

3. Sreepriya M. et al., Effect of Indigofera tinctoria Linn on liver antioxidant defense system during D-galactosamine/endotoxin-induced acute hepatitis in rodents. Indian J Exp Biol. 2001;39(2):181

▼Phellodendron Amurense (Amur Cork Tree )

Main ingredients:
Berberine
Actions based on scientific research: Anti-Inflammatory[1-4]

Anti-microbial[2]

Reduces sebum production[3]

References:
1. Cuéllar MJ, et al., Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 2001 Mar ;72(3):221-9.

2. Yu HH, et al., Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005;8(4):454-61.

3. Seki T, Morohashi M. Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands. Skin Pharmacol. 1993;6(1):56-60.

▼Angelica Polymorpha Sinensis (Dong Quai)

Main ingredients:
Ferulic acid
Actions based on scientific research: Anti-Inflammatory[1]

Heals wounds[2]

References:
1. Chao WW et al. Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol. 2010 May 27;129(2):244-9. Epub 2010 Apr 3.

2.Zhao H et al., SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin/severe-combined immunodeficiency mouse chimera. Wound Repair Regen. 2006 Sep-Oct;14(5):593-601.

▼Taraktogenos Kurzii

Main ingredients:
Flavonoids
Actions based on scientific research: Anti-Inflammatory[1]

Anti-bacterial[2]

References:
1.Lima JA, Oliveira AS, de Miranda AL, Rezende CM, Pinto AC. Anti-inflammatory and antinociceptive activities of an acid fraction of the seeds of Carpotroche brasiliensis (Raddi) (Flacourtiaceae). Braz J Med Biol Res. 2005 Jul;38(7):1095-103. Epub 2005 Jul 4.

2.Levy L. The activity of chaulmoogra acids against Mycobacterium leprae. Am Rev Respir Dis. 1975 May;111(5):703-5.

▼Sanguisorba Officinalis (Great Burnet)

Main ingredients:
Gallic acid, tannic Acid
Actions based on scientific research: Anti-allergic - inhibits histamine release[1]

Anti-inflammatory[2]

Anti-microbial[3]

Anti-oxidant[4]

References:
1. Shin TY. et al., Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions. Immunopharmacol Immunotoxicol. 2002. 24(3):455-68.

2. Ravipati AS. et al., Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complement Altern Med. 2012. 6;12(1):173.

3. Kokoska L. et al., Screening of some Siberian medicinal plants for antimicrobial activity. J Ethnopharmacol. 2002. 82(1):51-3.

4. Masaki H. et al., Active-oxygen scavenging activity of plant extracts. Biol Pharm Bull. 1995.18(1):162-6

5. Plant extracts for the treatment and prevention of infection [App. No. PCT/IL2011/050081; Pub. No. WO 2012/090205 * International phase

▼Chrysanthemum Indicum

Main ingredients:
Ailanthone, toosedanin
Actions based on scientific research: Anti-allergic (inhibits histamine release)[1,2]

Potent anti-inflammatory properties down-regulating TH2 cytokines such as IL-4 and IL-13[3,4]

References:
1. Kumar D. et al., Antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb. Pharmacognosy Res. 2011. 3(3):220-4.

2. Kang TH. et al., Ailanthus altissima swingle has anti-anaphylactic effect and inhibits inflammatory cytokine expression via suppression of nuclear factor-kappaB activation. In Vitro Cell Dev Biol Anim. 2010. 46(1):72-81.

3. Jin M. et al., Antiasthmatic activity of luteolin-7-O-glucoside from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model. Biol Pharm Bull. 2009. 32(9):1500-3.

4. Jin MH. et al., Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. Biol Pharm Bull. 2006. 29(5):884-8.

5. PCT/IL2011/050081; Pub. No. WO 2012/090205 * International phase

▼Ailanthus Altissima (Tree of Heaven)

Main ingredients:
Linarin

Actions based on scientific research: Anti-Inflammatory[1]

Anti-oxidative[2]

References:
1. Han S. et al., The effect of linarin on LPS-induced cytokine production and nitric oxide inhibition in murine macrophages cell line RAW264.7. Arch Pharm Res. 2002. 25(2):170-7.

2. Huang C. et al., Study on spectral properties of Chinese herbal medicines additives in cosmetic. Guang Pu Xue Yu Guang Pu Fen Xi. 2004, 24(12):1649-51.